学术活动
学术活动

PSC 卓越论坛

2018-06-06

 

PSC Distinguished Seminar Series

Title: CRISPR from prokaryotes to eukaryotes.

Speaker: Prof. Francis JM Mojica, University of Alicante, Spain

Time: 14:00 pm

Day/Date: June 6th, 2018 (Wednesday)

Host PI: Prof. Rosa Lozano-Duran& Prof. Alberto P. Macho

Venue: PSC Auditorium

 Abstract: 

Francisco Juan Martínez Mojica (Elche, October 5, 1963), usually known as Francisco JM Mojica, is a Spanish microbiologist at the University of Alicantein Spain, known for his research on the CRISPR gene editing technique. In 1993 repeats were observed   in the archaeal rganisms Haloferax and Haloarcula species, and their function was studied by Francisco Mojica. Although his hypothesis turned out to be wrong, Mojica surmised at the time that the clustered repeats had a role in correctly segregating replicated DNA into daughter cells during cell division because plasmids and chromosomes with identical repeat arrays could not coexist in Haloferax volcanii. Transcription of the interrupted repeats was also noted for the first time. By 2000, Mojica's group had identified interrupted repeats in 20 species of microbes.

In 2001, Mojica and Ruud Jansen, who was searching for additional interrupted repeats, proposed the acronym CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) to alleviate the confusion stemming from the numerous acronyms used to describe the sequences in the scientific literature.

2017 Mojica was a winner of the Albany Medical Center Prize.