PSC Frontier Seminar series
Title: Establishment and Maintenance of Epigenetic Information
Speaker: Prof. Bing Zhu, Institute of Biophysics, Chinese Academy of Sciences
Time: 1:30 pm
Day/Date: December 4th, 2018 (Tuesday)
Host PI: Prof. Jiamu Du
Venue: PSC Auditorium
DNA is unarguably the carrier of genetic information. However, DNA sequence alone cannot explain how hundreds of cell types in a complex multi-cellular organism, such as a human individual can possess distinct transcription programs, while sharing the same genetic information. This is believed to be achieved by fine-tuning our genetic information with a so-called “epigenetic” system. To fulfill the two basic tasks challenging the multi-cellular organisms, epigenetic system must simultaneously offer dual characteristics, “Plasticity & Inheritability”. Plasticity allows the transformation of one genome into hundreds of epigenomes and transcriptomes, whereas inheritability permits the maintenance of every single epigenome and its corresponding transcriptome.
We are interested in several dimensions of the epigenetic system. Primarily, we would like to understand how epigenetic information is inherited during mitotic divisions and how epigenetic information is established during germ cell maturation, stem cell differentiation and development. In this talk, I will highlight some of our recent progresses along these directions.
The seminar will be delivered in English.