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PSC Frontier Seminar Series

Title: Role of Autophagy in plant-virus interactions
Speaker: Prof. Yule Liu, School of Life Sciences, Tsinghua University
Time: 9:30am
Day/Date: April 28th, 2017 (Friday)
Host PI: Prof. Rosa Lozano-Duran
Venue: PSC Auditorium
Autophagy is an evolutionarily conserved process that recycles damaged or unwanted cellular components. We first found that autophagy is linked to plant immunity. Subsequently, cytoplastic glyceraldehyde-3-phosphate dehydrogenases (GAPC) were found to negatively autophagy and plant immunity. Recently, we found that the plant autophagic machinery targets the virulence factor βC1 of Cotton leaf curl Multan virus (CLCuMuV) for degradation through its interaction with the key autophagy protein ATG8. A V32A mutation in βC1 abolished its interaction with NbATG8f, and virus carrying βC1V32A showed increased symptoms and viral DNA accumulation in plants. Furthermore, silencing of autophagy-related genes ATG5 and ATG7 reduced plant resistance to the DNA viruses CLCuMuV, Tomato yellow leaf curl virus, and Tomato yellow leaf curl China virus, whereas activating autophagy by silencing GAPC genes enhanced plant resistance to viral infection. Thus, autophagy represents a novel anti-pathogenic mechanism that plays an important role in antiviral immunity in plants.
This presentation will be delivered in English and welcome to attend.

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