Title: Cryptochromes and blue-light regulation of proteome in plants
Speaker: Prof. Chentao Lin, University of California, Los Angeles
Time: 3:00 pm
Day/Date: Monday /July 24th, 2017
Host PI: Prof. Tongda Xu
Venue: PSC Auditorium
Cryptochromes are blue-light receptors that regulate development and the circadian clock in plants and animals. We found that Arabidopsis cryptochrome 2 (CRY2) undergoes blue light–dependent homodimerization to become physiologically active. We identified BIC1 (blue-light inhibitor of cryptochromes 1) as an inhibitor of plant cryptochromes that binds to CRY2 to suppress the blue light–dependent dimerization, photobody formation, phosphorylation, degradation, and physiological activities of CRY2. We hypothesize that regulated dimerization governs homeostasis of the active cryptochromes in plants and other evolutionary lineages.
Prof. Chentao Lin currently is professor from UCLA, and also director in UCLA-FAFU Joint Center. Prof. Lin got Ph.D in Michigan state University in 1992 and postdoc training in University of Pennsylvania. From 1996, he established his lab in UCLA, and became professor in 2005. His lab interested in deciphering the signal transduction mechanisms of the blue-light receptor cryptochrome, and we use Arabidopsis as our model organism in our study. They are currently employing molecular genetic approaches to dissecting the signal perception and transduction mechanisms of CRY2.