学术活动
研究组
 
           

陶纬国



电话:(86) 21-57078239
Email: watao@purdue.edu

研究方向

蛋白质与代谢组学
研究工作

The laboratory utilizes chromatography and mass spectrometry to investigate 1) protein post-translational modifications and structure-function aspects involved in plant growth and development; 2) proteins that help plants acclimate to environmental stresses such as drought, salinity, temperature extremes, and nutrient limitation; and 3) protein-protein interactions and biological pathways that mediate plant defence to bacterial and viral pathogens. We aim to establish existing proteomics methods and develop newly advanced techniques together with additional scientific resources to meet the demands of cutting-edge plant science and biomedical research.

Research efforts focus on the large-scale identification and quantification of proteins (i.e. proteome) extracted from plant cells and tissues, particularly those post-translationally modified by phosphorylation, glycosylation, ubiquitination and acetylation. Such analyses will localize the modifications on protein three-dimensional structural domains, and help to establish their influence on the activity, stability, degradation and conformation of plant enzymes, and to determine the regulatory role relevant to plant metabolism, growth and development. Through studying protein-protein interactions, we also develop quantitative proteomics strategies to resolve the signaling pathways of viral infection, proliferation, interaction, and immunization in host cells, which will ultimately develop plant varieties that are highly resistant to diseases.