PSC Frontier Seminar series
Title: Regulation and function of Calcium-Dependent Protein Kinases as decoders of calcium changes during stress signalling and development in plants
Speaker: Prof. Tina Romeis, Biochemistry of Plant Interactions, Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany
Time: 10:00 am
Day/Date: Apr. 29th, 2019 (Monday)
Host: Prof. Jian-Kang Zhu
Venue: PSC auditorium
Calcium-triggered intracellular signalling is a prerequisite to mount abiotic and biotic stress responses, and evidence for Ca2+-dependent regulation of plant growth and development exists. Calcium-dependent protein kinases (CDPKs) combine within a single molecule a calcium-sensing domain which contains in general 4 EF-hand calcium-binding motifs and a protein kinase effector domain. Accordingly, CDPKs function as decoders that sense and translate (induced) cytoplasmic changes in Ca2+ into further downstream signalling events. CDPKs participate in abiotic stress responses in ABA-signalling and in the control of the stomatal aperture. In innate immune signalling, CDPKs have been identified as positive and as negative regulators for both local early and late systemic defence responses in PTI and ETI. Our current research focuses on the primary biochemical enzyme activation mechanism as well as on the identification of biological processes and genuine in vivo phosphorylation substrates for distinct CDPK isoforms. In particular, we aim for biochemical mechanisms how CDPKs mediate calcium specificity, and how calcium signals are decoded by CDPK isoforms into different signalling outputs.
The seminar will be delivered in English.