学术活动
学术活动

植物科学前沿系列讲座

2019-11-22

PSC Frontier Seminar series
Title: 3D genomics and its application in plants
Speaker: Prof. Guoliang Li, College of Informatics, Huazhong Agricultural University
Time: 10:00 am
Day/Date: November 25th, 2019 (Monday)
Host: Prof. Jian-Kang Zhu
Venue: PSC Auditorium
 
Abstract:
The three-dimensional (3D) architecture of the eukaryotic genomes plays significant roles in DNA replication, gene transcription and other biological functions. However, most of the 3D genomics studies were done in animals. In this report, I will talk the background of 3D genomics, and then introduce our work in maize and rice. With long-reads ChIA-PET, we have generated high-resolution chromatin interactions in maize and rice. The results show that the chromatin interactions could link distal regulatory elements to their target genes. For example, most of the known enhancers in maize were linked to their target genes through chromatin interactions. The potential target genes of GWAS SNPs and QTLs associated with important agronomic traits were identified through chromatin interactions too. The promoter–promoter interacting genes tend to be transcribed cooperatively. In rice, we generated chromatin interactions associated with active markers (H3K4me3 and RNAPII) and those associated with repressive mark (H3K9me2), which separated the chromatin architecture into different independent spatial interacting modules with distinct transcriptional potential. Our work may provide some clues for 3D genomic study in other plants.
 
The seminar will be delivered in English.