学术活动
学术活动

植物科学前沿系列讲座

2021-03-29

PSC Frontier Seminar series

Title: Regulation of histone demethylase specificity ensures meiotic chromosome condensation in plants
Speaker: Prof. Yingxiang Wang ,School of Life Sciences, Fudan University
Time: 2:30 pm
Day/Date: March 30th, 2021 (Tuesday)
Host: Prof. Chao-Feng Huang
Venue: PSC Auditorium
 
Abstract:
Histone demethylation is crucial for proper chromatin structure and ensure normal development, and requires the large family of JmjC-containing demethylases, but the molecular mechanisms regulating their substrate specificity remain largely unknown. We show here that the substrate specificity of the Arabidopsis histone demethylase JMJ16 is broadened from H3K4 alone in somatic cells to both H3K4 and H3K9, when it binds to a meiocyte-specific histone reader MMD1. Consistently, the JMJ16 catalytic domain exhibits both H3K4 and H3K9 activities. Moreover, the JMJ16 C-terminal FYR domain interacts with the JMJ16 catalytic domain and likely restricts its substrate specificity. In contrast, MMD1 can compete with the JMJ16 N-terminal catalytic domain for binding to the FYR-C domain, thereby expanding JMJ16 substrate specificity by preventing the FYR domain from binding to the catalytic domain. We propose that MMD1 and JMJ16 together in male meiocytes promote gene expression in H3K9me3-dependent manner, thus contributing meiotic chromosome condensation.