学术活动
导师介绍

赵杨
研究员,博士生导师


Email: zhaoyang@sibs.ac.cn
Phone:(86) 21-54924328

个人简介:
2016年12月-今:中国科学院上海植物逆境生物学研究中心,研究员
2012年2月-2016年12月:普渡大学, 博士后
2011年6月-2012年1月:中国农业大学,博士后
2009年6月-2011年6月:北京生命科学研究所,博士后
2009年:中国农业大学,北京生命科学研究所,植物学博士
2004年:中国农业大学,生物学学士

研究方向:
渗透胁迫信号传导

研究工作:
在自然界中,植物生长在一个多变的环境中。为了生存和物种延续,植物必须适应各种环境胁迫。干旱造成的渗透胁迫严重影响植物的生长与存活,导致作物减产和草木死亡,威胁着人类的粮食安全和生活质量,并造成严重的经济损失。研究渗透胁迫的信号传导机制,对提高作物以及草木的抗旱能力有着重要的指导意义。

钙信号是植物对渗透胁迫的瞬间响应,它是目前已知的最快速反应。通过筛选钙信号异常突变体,我们可以找到渗透胁迫信号的早期响应机制。钙信号的监测是很久以来的技术瓶颈,导致渗透胁迫的早期通路难有突破。我们使用转基因拟南芥突变体为材料,建立了一套优化的筛选系统,采用遗传筛选并从中找到一些钙信号降低的突变体。通过对相关基因的克隆,我们希望找到渗透胁迫信号传导的部分节点。
渗透胁迫能引起植物体内ABA浓度的升高,从而激活ABA信号通路并引起下游相应。目前,我们正在探索ABA对衰老、休眠、源库转运的调控机理,以及ABA信号对其他激素信号传导的调控。这些研究有着重要的理论意义和潜在的实际应用价值。

研究生情况:
指导硕士研究生3名

代表性论文:
1. Zhao, Y.*, Chan, Z.*, Gao, J., Xing, L., Cao, M., Yu, C., Hu, Y., You, J., Shi, H., Zhu Y., Gong, Y., Mu, Z., Wang, H., Deng, X., Wang, P., Bressan, R.A., Zhu, J.K. (2016). The ABA receptor PYL9 promotes drought resistance and leaf senescence. Proc Natl Acad Sci U S A. *Co-first authors.
2. Xing, L.*, Zhao, Y.*, Gao, J.*, Xiang, C., Zhu, J.K. (2016). The ABA receptor PYL9 together with PYL8 plays an important role in regulating lateral root growth. Scientific Reports. *Co-first authors.
3. Zhao, S., Jiang, Y., Zhao, Y., Huang, S., Yuan, M., Zhao, Y., Guo, Y. (2016) Casein kinase1-like protein2 controls actin filament stability and stomatal closure via phosphorylation of actin depolymerizing factor. Plant Cell.
4. Hou, Y.J., Zhu, Y., Wang, P., Zhao, Y., Xie, S., Batelli, G., Wang, B., Duan, C., Wang, X., Xing, L., Lei M., Zhu X., Zhu J.K. (2016). Type One Protein Phosphatase 1 (TOPP1) and its regulatory protein Inhibitor 2 (AtI-2) negatively regulate ABA signaling. Plos Genetics.
5. Lind, C., Dreyer, I., Lopez-Sanjurjo, E.J., von Meyer, K., Ishizaki, K., Kohchi, T., Lang, D., Zhao, Y., Kreuzer, I., Al-Rasheid, K.A., et al. (2015). Stomatal guard cells co-opted an ancient ABA-dependent desiccation survival system to regulate stomatal closure. Curr Biol 25, 928-935.
6. Wang, P., Du, Y., Hou, Y.J., Zhao, Y., Hsu, C.C., Yuan, F., Zhu, X., Tao, W.A., Song, C.P., and Zhu, J.K. (2015). Nitric oxide negatively regulates abscisic acid signaling in guard cells by S-nitrosylation of OST1. Proc Natl Acad Sci U S A 112, 613-618.
7. Wang, C., Zheng, Y., Zhao, Y., Zhao, Y., Li, J., and Guo, Y. (2015). SCAB3 Is Required for Reorganization of Actin Filaments during Light Quality Changes. Journal of Genetics and Genomics 42, 161-168.
8. Zhou, X., Hao, H., Zhang, Y., Bai, Y., Zhu, W., Qin, Y., Yuan, F., Zhao, F., Wang, M., Hu, J., Xu, H., Guo, A., Zhao, H., Zhao, Y., et al. (2015). SOS2-LIKE PROTEIN KINASE5, an SNF1-RELATED PROTEIN KINASE3-Type Protein Kinase, Is Important for Abscisic Acid Responses in Arabidopsis through Phosphorylation of ABSCISIC ACID-INSENSITIVE5. Plant Physiology 168, 659-676.
9. Duan, C.G., Zhang, H., Tang, K., Zhu, X., Qian, W., Hou, Y.J., Wang, B., Lang, Z., Zhao, Y., Wang, X., et al. (2015). Specific but interdependent functions for Arabidopsis AGO4 and AGO6 in RNA-directed DNA methylation. EMBO J 34, 581-592.
10. Zhao, Y.*, Xing, L.*, Wang, X., Hou, Y.J., Gao, J., Wang, P., Duan, C.G., Zhu, X., and Zhu, J.K. (2014). The ABA Receptor PYL8 Promotes Lateral Root Growth by Enhancing MYB77-Dependent Transcription of Auxin-Responsive Genes. Sci Signal 7, ra53. (Cover story and feature article commented by Jason D. Berndt, Sci. Signal. 7, ra53. This article has been highlighted in Science). *Co-first authors.
11. Sridharamurthy, M., Kovach, A., Zhao, Y., Zhu, J.K., Xu, H.E., Swaminathan, K., and Melcher, K. (2014). H2O2 Inhibits ABA-Signaling Protein Phosphatase HAB1. PLoS One 9, e113643.
12. Zhao Y.*, Chan, Z.*, Xing, L., Liu, X., Hou, Y.J., Chinnusamy, V., Wang, P., Duan, C., and Zhu, J.K. (2013). The unique mode of action of a divergent member of the ABA-receptor protein family in ABA and stress signaling. Cell Res 23, 1380-1395. *Co-first authors.
13. Liu X., Zhang H., Zhao Y., Feng Z., Li Q., Yang H-Q., Luan S., Li J., He Z-H. (2013). Auxin controls seed dormancy through stimulation of abscisic acid signaling by inducing ARF-mediated ABI3 activation in Arabidopsis. Proc Natl Acad Sci U S A 110 (38):15485-90.
14. Ge B.*, Yang D-H.*, Zhao Y.*, Ha, S., Yang, F., Ma, J., Gao, X.S., Wang, Z.M., and Zhu, J.K. (2013). Interactions between soybean ABA receptors and type 2C protein phosphatases. Plant Mol Biol 83, 651-664 (Cover story). *Co-first authors.
15. Wang X., Duan C-G., Tang K., Wang B., Zhang H., Lei M., Lu K., Mangrauthia S-K., Wang P., Zhu G., Zhao Y., Zhu J-K. (2013). An RNA-binding protein regulates plant DNA methylation by controlling mRNA processing at intronic heterochromatin-containing genes. Proc Natl Acad Sci U S A 110 (38):15467-72.
16. Cao M., Liu X., Zhang Y., Xue X., Zhou X-E., Melcher K., Gao P., Wang F., Zeng L., Zhao Y., Zhao Y., Deng P., Zhong D., Zhu J-K., Xu H-E., and Xu Y. (2013) An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. Cell Research 23:1043–1054.
17. Zhang W., Zhao Y., Guo Y., and Ye K. (2012). Plant actin-binding protein SCAB1 is dimeric actin cross-linker with atypical pleckstrin homology domain. J Biol Chem 287, 11981-11990.
18. Pan Z., Zhao Y., Zheng Y., Liu J., Jiang X., Guo Y. (2012). A high-throughput method for screening Arabidopsis mutants with disordered abiotic stress-induced calcium signal. J Genet Genomics 39(5): 225-235.
19. Zhao Y., Zhao S., Mao T., Qu X., Cao W., Zhang L., Zhang W., He L., Li S., Ren Su., Zhao J., Zhu G., Huang S., Ye K., Yuan M., and Guo Y. (2011). The plant-specific actin binding protein SCAB1 stabilizes actin filaments and regulates stomatal movement in Arabidopsis. Plant Cell 23: 2314-2330.
20. Yang Y., Zhao Y., Zhu G. (2011). pH induced elastic modulus of guard cell wall in stomatal movement. Chinese Science Bulletin 56:3554-3557.
21. Zhao J., Zhang W., Zhao Y., Gong X., Guo L., Zhu G., Wang X., Gong Z., Schumaker K.S., and Guo Y. (2007). SAD2, an importin -like protein, is required for UV-B response in Arabidopsis by mediating MYB4 nuclear trafficking. Plant Cell 19: 3805-3818.