学术活动
导师介绍

王鹏程
研究员,博士生导师


Email: pcwang@sibs.ac.cn

个人简介:
1996-2000,河南大学,学士
2000-2003,河南大学,植物学硕士
2003-2005,河南大学生命科学学院,助教
2005-2010,河南大学,植物学博士
2010-2011,河南大学生命科学学院,副教授
2011-2016,Purdue University,园艺系,Research Associate
2017至今,中国科学院上海植物逆境生物学研究中心,研究员

研究方向:
蛋白激酶与植物逆境生物学

研究工作:
蛋白磷酸化是重要的转录后修饰过程之一。蛋白激酶通过磷酸化调控底物蛋白的稳定性、活性、定位等性质,参与了几乎所有的生物学过程。相对于其它生物基因组,植物基因组中有更多的基因编码蛋白激酶,可能与植物细胞中更复杂的信号感受和转导机制有关。已知MAPK、CDPK、SnRK2/3等多个蛋白激酶家族参与了植物对于干旱、渗透胁迫、盐胁迫等非生物逆境的应答过程,但对于激活这些蛋白激酶的上游途径、这些蛋白激酶活性的调控、以及这些蛋白激酶下游的生物学过程仍缺乏了解。
我们将以参与植物非生物逆境胁迫应答的蛋白激酶为研究对象,利用先进的磷酸化蛋白组学技术,在蛋白组水平鉴定参与的植物非生物胁迫应答过程的蛋白激酶的底物,构建参与非生物胁迫应答过程的蛋白激酶——底物调控网络,并解析蛋白激酶参与的下游生物学过程。针对一些重要的蛋白激酶——底物组合进行深入研究,通过遗传学、生物化学和细胞生物学研究方法解析蛋白激酶调控底物蛋白功能的分子机制。同时筛选并鉴定参与干旱、渗透、盐等非生物逆境应答的新的早期信号组分,研究植物感受和适应非生物胁迫的分子机制。

代表性论文:
1.Jun Yan, Pengcheng Wang, Bangshing Wang, Chuan-Chih Hsu, Kai Tang, Hairong Zhang, Yueh-Ju Hou, Yang Zhao, Qiming Wang, Chunzhao Zhao, Xiaohong Zhu, W. Andy Tao, Jianming Li, Jian-Kang Zhu. The SnRK2 kinases modulate miRNA accumulation in Arabidopsis. PLoS Genetics 2017, 13(4): e1006753.
2.Yueh-Ju Hou, Yingfang Zhu, Pengcheng Wang, Yang Zhao, Shaojun Xie, Giorgia Batelli, Bangshing Wang, Cheng-Guo Duan, Xingang Wang, Lu Xing, Mingguang Lei, Xiaohong Zhu, Jian-Kang Zhu. Type One Protein Phosphatase 1 (TOPP1) and its regulatory protein Inhibitor 2 (AtI-2) negatively regulate ABA signaling. PLOS Genetics 2016, 12: e1005835.
3.Pengcheng Wang, Yanyan Du, Yueh-Ju Hou, Yang Zhao, Chuan-Chih Hsu, Feijuan Yuan, Xiaohong Zhu, W Andy Tao, Chun-Peng Song, Jian-Kang Zhu. Nitric oxide negatively regulates abscisic acid signaling in guard cells by S-nitrosylation of OST1. Proceedings of the National Academy of Sciences 2015, 112: 613-618 (Highly Cited Paper by Essential Science Indicators, Commentary: Say "NO" to ABA signaling in guard cells by S-nitrosylation of OST1. [Sci China Life Sci. 2015 58: 313-314])
4.Pengcheng Wang, Jian-Kang Zhu, Zhaobo Lang. Nitric oxide suppresses the inhibitory effect of abscisic acid on seed germination by S-nitrosylation of SnRK2 proteins. Plant Signaling & Behavior 2015, 10(6): e1031939.
5.Ying Zhang, Pengcheng Wang, Wanchen Shao, Jian-Kang Zhu, Juan Dong. The BASL polarity protein controls a MAPK signaling feedback loop in asymmetric cell division. Developmental Cell 2015, 33: 136–149 (co-first author, recommended by Faculty of 1000)
6.Pengcheng Wang, Liang Xue, Giorgia Batelli, Shinyoung Lee, Yueh-Ju Hou, Michael J Van Oosten, Huiming Zhang, W Andy Tao, Jian-Kang Zhu. Quantitative phosphoproteomics identifies SnRK2 protein kinase substrates and reveals the effectors of abscisic acid action. Proceedings of the National Academy of Sciences 2013, 110: 11205-11210 (Highly Cited Paper by Essential Science Indicators, recommended by Faculty of 1000)
7.Liang Xue, Pengcheng Wang, Pianpian Cao, Jian-Kang Zhu, Weiguo Andy Tao. Identification of ERK1 direct substrates using stable isotope labeled kinase assay-linked phosphoproteomics. Molecular & Cellular Proteomics 2014, 13: 3199-3210
8.Liang Xue, Pengcheng Wang, Lianshui Wang, Emily Renzi, Predrag Radivojac, Haixu Tang, Randy Arnold, Jian-Kang Zhu, Weiguo Andy Tao. Quantitative measurement of phosphoproteome response to osmotic stress in Arabidopsis based on Library-Assisted eXtracted Ion Chromatogram (LAXIC). Molecular & Cellular Proteomics 2013, 12: 2354-2369
9.Pengcheng Wang, Yanyan Du, Xiaoliang Zhao, Yuchen Miao, Chun-Peng Song. The MPK6-ERF6-ROS-Responsive cis-Acting Element7/GCC box complex modulates oxidative gene transcription and the oxidative response in Arabidopsis. Plant Physiology 2013, 161: 1392-1408 (Highly Cited Paper by Essential Science Indicators)
10.Pengcheng Wang, Yanyan Du, Chun-Peng Song. Phosphorylation by MPK6: a conserved post-transcriptional modification mediates nitrate reductase activation and NO production? Plant Signaling & Behavior 2011, 6: 889-891
11.Pengcheng Wang, Yanyan Du, Yuan Li, Dongtao Ren, Chun-Peng Song. Hydrogen peroxide-mediated activation of MAP kinase 6 modulates nitric oxide biosynthesis and signal transduction in Arabidopsis. The Plant Cell 2010, 22: 2981-2998 (Highly Cited Paper by Essential Science Indicators, recommended by Faculty of 1000)